This page explains how Pregnyl (human chorionic gonadotropin (hCG)) is used in IVF treatment. All information is educational. Talk to your doctor about your specific protocol and any questions or concerns about your medications.
Overview
| Brand name | Pregnyl, Novarel |
|---|---|
| Generic name | human chorionic gonadotropin (hCG) |
| Category | Trigger Shot |
| How it is given | intramuscular injection |
| Common dosages | 5,000 IU, 10,000 IU |
| Typical timing | Single injection given approximately 34 to 36 hours before egg retrieval |
What to expect: common side effects
Side effects vary from person to person. Many people experience only mild effects while others find them more significant. All of these experiences are valid. Report any severe or unexpected symptoms to your care team right away.
- Injection site pain (intramuscular injections are typically more uncomfortable than subcutaneous)
- Bloating and pelvic pressure
- Headache
- Nausea
- Mood changes
- Risk of OHSS in high responders
Storage instructions
Refrigerate powder vials between 2C and 15C (36F to 59F). Once reconstituted, refrigerate and use within 60 days. Diluent can be stored at room temperature.
Traveling with Pregnyl
Pregnyl powder vials require refrigeration. Pack with ice packs in a cool bag. Declare as medical necessity and carry your prescription documentation. Mix only when ready to use.
Tips from the IVF community
These are practical suggestions shared by people who have been through IVF. They are not a substitute for your clinic's guidance.
- Intramuscular injections (IM) are given into the muscle of the upper outer buttock or thigh. Your nurse will demonstrate the technique.
- Applying warmth to the injection site before and after can reduce discomfort
- Partner involvement in IM injections can make the process easier for both of you
- Log the exact time of your trigger shot. Your entire retrieval schedule depends on this timing.
- If IM injections feel overwhelming, ask your clinic about Ovidrel (subcutaneous) as an alternative.
Track this medication with TrackMyIVF
Set dose reminders, log side effects, and share your medication timeline with your care team. TrackMyIVF keeps everything in one place so you never miss a dose.
Learn about TrackMyIVFFrequently Asked Questions
What is the difference between Pregnyl and Ovidrel?
Both Pregnyl and Ovidrel are hCG-based trigger shots that trigger final egg maturation before retrieval. Pregnyl is derived from urine and given as an intramuscular (IM) injection, while Ovidrel is a recombinant form given subcutaneously. Many patients find subcutaneous injections less painful, but your doctor may have specific reasons for recommending one over the other.
How do I mix Pregnyl?
Pregnyl comes as a powder that must be mixed with a sterile diluent before injection. Your clinic will walk you through the preparation. Generally, you inject the diluent into the powder vial, gently swirl until dissolved, and draw the solution into a syringe for IM injection.
Why does the trigger shot timing matter so much?
The hCG trigger initiates a precise hormonal cascade that leads to ovulation. Retrieval is scheduled 34 to 36 hours later to catch eggs just before they would be released naturally. If the timing is off by several hours, some eggs may be lost. Set multiple reminders and confirm the exact time with your clinic.
Will a home pregnancy test be positive after Pregnyl?
Yes, because Pregnyl is hCG, it will trigger a positive result on a home pregnancy test for several days after injection. Avoid testing at home after the trigger shot. Your clinic will test your blood at the right time to get an accurate early pregnancy reading.
Medical disclaimer: This page provides general educational information only. It is not medical advice and should not replace guidance from your doctor, nurse, or reproductive endocrinologist. Every person's treatment is unique. Always consult your care team before making any decisions about your medications or treatment plan.
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About the author
Viv
BSc, Patient Advocate
Founder, TrackMyIVF
I built TrackMyIVF because I needed it during my own journey. Every feature comes from real experience.